Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic controlResearch article Published on 2022-12-012022-10-05 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication [DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article
Repurposing of HIV/HCV protease inhibitors against SARS-CoV-2 3CLproArticle Published on 2022-11-012022-11-15 Journal: Antiviral Research [Category] SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro 3CLpro acute respiratory syndrome Anti-coronavirus drug antiviral drug applied caused cleavage Compound coronavirus COVID-19 outbreak dose-dependent manner Efficiency energy transfer exhibited feasibility HCV in vitro inhibited inhibitor inhibitors Mutation omicron pathogen predicted protease Protease inhibitor protease inhibitors quantification reproducibility repurposing SARS-CoV-2 Screening Screening assay Severe acute respiratory syndrome coronavirus 2. Support variants virus replication [DOI] 10.1016/j.antiviral.2022.105419 PMC 바로가기
In vitro testing of salt coating of fabrics as a potential antiviral agent in reusable face masksArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] added airway Antiviral cloth mask cloth masks collected conditions coronavirus disease COVID-19 cultures dependent on dilutions distribution Effectiveness eight epithelia epithelial evaluated Face mask Face masks H3N2 handling incubated mandatory Masks pandemic protocol quantified reduced relative remained risk Sodium chloride tested turn viral replication virus particle virus replication wearing face mask [DOI] 10.1038/s41598-022-21442-7 PMC 바로가기
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infectionArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] 3D cultures activate added Air-liquid interface air-liquid interface (ALI) airway airway epithelium Antigen presentation antiviral immune response basolateral side cell type co-culture Contact Course Culture cytokine production cytokine release demonstrated driven by epithelial epithelial cells evaluate HAE hMDM hMDMs Human airway epithelium human airway epithelium (HAE) human monocyte-derived macrophage immune response in viral infected cell Infection Innate immunity lung Macrophage macrophages macrophages. phagocyte primary human airway recruitment Replication SARS-CoV-2 SARS-COV-2 infection Spread the SARS-CoV-2 tissue macrophage transfer virus virus replication [DOI] 10.3389/fimmu.2022.991991 PMC 바로가기
Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19Research article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory distress Affect Algorithm Analysis antiviral therapy Brain causes clinical study Col1a1 collagen Comorbidities Complication complications component Control coronavirus COVID-19 COVID-19 patients develop diagnostic drug drug repositioning FDA approved drug Genetic help immune system independent Infection Inflammation Inflammatory response Influenza involved kidneys Lungs machine learning methodology offer other organ pathway Pathways Patient performed principal Regulation response responsible Result reveal RSV SARS-CoV-2 SARS-COV-2 infection severity Side effect Side effects Small scale genetic signature susceptibility syndrome the disease the interferon Transcriptome transcriptomic transcriptomic analysis transcriptomic data virus replication [DOI] 10.1016/j.compbiomed.2022.106029 [Article Type] Research article
SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variantArticle Published on 2022-09-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] Activation analyzed antiviral response arising Beta Calu-3 cell calu-3 cells cellular circumvent comparable replication correlated COVID-19 infection Delta Effect epithelial Evolution genomic host cell human lung Immunity induce innate immune innate immune activation Innate immunity interferon interferon response ISG ISGs mRNA expression Mutation mutations omicron pandemic produced Replication replication efficiency SARS-CoV-2 SARS-CoV-2 variant signaling pathways STAT2 stimulated Transmission Treatment vaccination Vaccine variant variants variants of concern variants. variations Viral RNA virus virus replication while [DOI] 10.3389/fimmu.2022.1016108 PMC 바로가기
Comparison of Intracellular Transcriptional Response of NHBE Cells to Infection with SARS-CoV-2 Washington and New York StrainsArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] 24 hour acute respiratory syndrome affected analyzed bioinformatics caused Cell cellular coronavirus COVID-19 D614G mutation Data mining death DEGs different time point differentially expressed gene dysregulated Effect epithelial experiment Gene ontology Genome global pandemic GO terms Host host cells host response Host transcriptional response host-virus hpi identify immune IMPROVE include Infection infections inhibited Intracellular mechanism Mutation New York NHBE pathway Pathways Patient positive Post-infection reported response resulting RNA sequencing data SARS-CoV-2 SARS-CoV-2 isolate severe disease shown Signaling signaling pathways similarity stability strain Strains These data transcript translation viral isolate viral spike protein Virology. virus virus replication Washington while Wuhan, China [DOI] 10.3389/fcimb.2022.1009328 PMC 바로가기
A computational study of metal-organic frameworks (MOFs) as potential nanostructures to combat SARS-CoV-2Article Published on 2022-09-202022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] ACE acute respiratory syndrome angiotensin-converting enzyme 2 antibody antiviral drug binding biological molecule carrier coronavirus COVID-19 Critical deformation determine drug host cells inhibitor Interaction investigated M pro MOF molecular nanobody non-structural protein protease Protein receptor S protein SARS-CoV-2 secondary structure Spike protein surface protein tested Vaccine virus replication [DOI] 10.1038/s41598-022-19845-7 PMC 바로가기
Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAsArticle Published on 2022-09-192022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] SARS, 변종, 치료제, [키워드] Antiviral antiviral activity Antiviral compounds antiviral medication Apoptosis cell line Corona Corona pandemic cytotoxicity facilitate FIVE flexible Ligand lung magnitude mutations peptide peptide RNA conjugates receptor reduce RNA SARS-CoV-2 sequence siRNA siRNA. suppression variants of concern variants of SARS-CoV-2 viral escape Viral load virus replication [DOI] 10.1002/anie.202204556 PMC 바로가기